RESEARCH ON AUTOPHAGY FETCHED YOSHINORI OHSUMI A NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE

 RESEARCH ON AUTOPHAGY FETCHED YOSHINORI OHSUMI  A NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE

The concept of autophagy is to make the body hungry.  When a person's body is hungry, then the cells of his body are also hungry.

These hungry cells will eat their own cells that are no longer useful or cells that have been damaged or dead cells, so as not to become garbage in the body; thus these dead cells will not produce anything that can harm the body. The importance of this process is that the body of a fasting person usually cleanse itself.

This scientist named Yoshinori Ohsumi has proven and found that when a person is hungry (fasting) in a period of not less than eight (8) hours and not more than sixteen (16), then the body will form a Special protein throughout the body called autophagisome.

The autophagisome can be analogized as a giant broom that collects useless dead cells that can harm the body and thereby remove them.

These dead cells are mostly produced by cancer cells and germ-shaped cells (viruses or bacteria) that cause disease.

The autophagisome protein destroys and eats the harmful cells, then releases them.

As a conclusion from this research, Doctor Yoshinori Ohsumi suggested that a person should undergo the practice of starvation (fasting).

This research has won the  NOBEL KEDOKTERAN AWARD to Doctor Yoshinori Ohsumi for his research which he celled AUTOPHAGI. The NOBEL Prize in Physiology or Medicine 2016 was awarded to Yoshinori Ohsumi “for his discoveries of mechanisms for autophagy.”

This means that the concept of Autophagy has actually been suggested by the prophet Muhammad (SAW) in over 15 centuries ago.

The word autophagy originates from the Greek words auto-, meaning "self", and phagein meaning "to eat".  Thus autophagy denotes "self eating". This concept emerged during the 1960's, when researchers first observed that the cell could destroy its contents by enclosing it in membranes, forming park-like vesicles that were transported to a recycling compartment, called the lysosome, for degradation.  Difficulties in studying the phenomenon meant that little was known until, in a series of brilliant experiments in the early 1990's Yoshinori Ohsumi used baker's yeast to identify genes essential for autophagy.

He then went on to elucidate the underlying mechanisms for autophagy in yeast and showed that similar machinery is used in our cells. 

Ohsumi's discoveries led to a new paradigm in our understanding of how the  cell recycles its contents. His discoveries opened the path to understanding the fundamental importance of autophagy in many physiological processes, such as in the adaptation to starvation or response to infection. Mutations in autophagy genes can cause disease, and the autophagic process is involved in several conditions including cancer and neurological disease.